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It can be said that cytokines are involved in autocrine signalling, paracrine signalling and endocrine signalling as immunomodulating agents.

Their definite distinction from hormones is still part of ongoing research.

Cytokines include chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors but generally not hormones or growth factors (despite some overlap in the terminology).

Cytokines are produced by a broad range of cells, including immune cells like macrophages, B lymphocytes, T lymphocytes and mast cells, as well as endothelial cells, fibroblasts, and various stromal cells; a given cytokine may be produced by more than one type of cell.

They act through receptors, and are especially important in the immune system; cytokines modulate the balance between humoral and cell-based immune responses, and they regulate the maturation, growth, and responsiveness of particular cell populations.

Some cytokines enhance or inhibit the action of other cytokines in complex ways.

A classification of cytokine receptors based on their three-dimensional structure has, therefore, been attempted.Further, as molecules, cytokines are not limited to their immunomodulatory role.Cytokines have been classed as lymphokines, interleukins, and chemokines, based on their presumed function, cell of secretion, or target of action.As scientists learned more, it was understood that these proteins and others were part of a broader class of proteins involved in self-defense, and should be called "cytokines".

M) concentrations that can increase up to 1,000-fold during trauma or infection.

Several inflammatory cytokines are induced by oxidative stress.



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